Risk Factors for Recurrence of HCC without Macrovascular Invasion after Curative Resection

HCC is the sixth most common malignancies worldwide (Parkin et al., 2005) and its incidence is continuous increasing recently (El-Serag et al., 1999). Surgical resection is regarded as a potentially curative treatment for patients with HCC and it has become a safe operation with very low morbidity and mortality rates because of the improvement in surgical techniques and perioperative managements (Fan et al., 1999). However, the long term survival remains unsatisfactory as results of high postoperative recurrence rate which was reported ranged from 65% to 80% in 5-year after primary surgery (Poon et al., 2002; Imamura et al., 2003; Kamiyama et al., 2009), and most of the postoperative recurrences occur in liver remnant (Poon et al., 1999; Taketomi et al., 2010). Intrahepatic recurrence of HCC after surgical resection could originate from either intrahepatic metastasis (IM) from the primary tumor or multicentric occurrence (MO)